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LY3437943 · Triple Agonist · GLP-1/GIP/Glucagon Triagonist
Next-generation triple hormone agonist with superior weight reduction vs. semaglutide
Typical Dose
1-2.5 mg once weekly (starting dose)
Route
Subcutaneous
Frequency
Once weekly
Cycle
12-48 weeks
Retatrutide simultaneously activates three hormone receptors: GLP-1, GIP, and glucagon. Phase 2 clinical trial data showed weight reductions exceeding 24% in obese subjects over 48 weeks, making it one of the most potent metabolic peptides under investigation. It works through synergistic activation of all three pathways to produce metabolic effects that exceed single or dual agonists.
Retatrutide activates GLP-1 receptors to suppress appetite and slow gastric emptying, GIP receptors to enhance insulin secretion and fat metabolism, and glucagon receptors to increase energy expenditure and hepatic glucose output. The synergistic activation of all three pathways produces additive metabolic effects that exceed those of dual or single agonists.
Typical Dose
1-2.5 mg once weekly (starting dose)
Dose Range
1-10 mg/week
Frequency
Once weekly
Route
Subcutaneous injection (stomach preferred; thighs or upper arms also acceptable)
Cycle Length
12-48 weeks
CLINICAL NOTES
Start at 1-2.5 mg once weekly for the first 4 weeks. Increase in 0.5 mg increments every 6-12 weeks as needed and tolerated. Inject subcutaneously into the stomach for best results. Titrate slowly to minimize GI side effects.
Vial Size
10 mg
BAC Water
1 mL (100 units)
Concentration
10 mg/mL
STEP-BY-STEP INSTRUCTIONS
Remove caps from the bacteriostatic water (BAC water) and Retatrutide vial. Clean both stoppers with alcohol swabs. Draw 100 units (1 mL) of BAC water and inject slowly into the Retatrutide vial. Gently swirl — do not shake. The solution is now 10 mg/mL.
DRAW VOLUME REFERENCE
| Dose | Units (U-100) | Volume (mL) |
|---|---|---|
| 1 mg | 10 units | 0.10 mL |
| 2 mg | 20 units | 0.20 mL |
| 2.5 mg | 25 units | 0.25 mL |
| 3 mg | 30 units | 0.30 mL |
| 5 mg | 50 units | 0.50 mL |
| 10 mg | 100 units | 1.00 mL |
STORAGE
Lyophilized powder: store in a cool, dry, dark area for up to 1 year. Once reconstituted: refrigerate and use within 45–60 days.
IMPORTANT DISCLAIMER
This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.
As a triple agonist (GLP-1/GIP/glucagon), retatrutide is typically run solo. Metabolic support peptides are the best complement.
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Tesamorelin's visceral fat targeting stacks well with retatrutide's broad metabolic action.
NAD+ supports mitochondrial function and energy metabolism alongside retatrutide's weight loss effects.
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