NAD+

Nicotinamide Adenine Dinucleotide · Beta-NAD+ · NAD

The master coenzyme for cellular energy, DNA repair, and sirtuin-driven longevity

Typical Dose

500 mg 2-3x weekly

Route

Subcutaneous

Frequency

2-3x weekly or daily

Cycle

Ongoing

Overview

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in all living cells, essential for hundreds of metabolic reactions. It plays a central role in cellular energy production (ATP synthesis), DNA repair via PARP enzymes, and gene expression regulation via sirtuins (SIRT1-7). NAD+ levels decline significantly with age, and this decline is associated with metabolic dysfunction, neurodegeneration, and accelerated aging.

Key Benefits

Cellular energy production support

DNA repair via PARP activation

Sirtuin (SIRT1-7) activation for longevity signaling

Mitochondrial biogenesis

Neuroprotection

Metabolic regulation

Mechanism of Action

NAD+ serves as an electron carrier in redox reactions of cellular respiration. It is also a substrate for sirtuins (SIRT1-7), which are NAD+-dependent deacetylases that regulate gene expression, DNA repair, and metabolic adaptation. Declining NAD+ with age reduces sirtuin activity and impairs DNA repair capacity.

Dosing Protocol

Typical Dose

500 mg 2-3x weekly

Dose Range

250-1000 mg per session

Frequency

2-3x weekly or daily

Route

Subcutaneous injection or IV infusion

Cycle Length

Ongoing

CLINICAL NOTES

IV infusion provides highest bioavailability. Administer slowly to minimize flushing. Can be combined with NMN or NR for synergistic effect.

Save to Library

Reconstitution calculator and cycle planner pre-filled with NAD+ defaults

Side Effects & Safety

Flushing (especially with rapid IV administration)

Nausea

Headache

Fatigue (transient)

Injection site discomfort

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.