Cagrilintide
AM833 · Long-acting amylin analog · CagriSema component
Long-acting amylin analog with additive weight loss when combined with semaglutide
Typical Dose
1.2 mg once weekly
Route
Subcutaneous
Frequency
Once weekly
Cycle
12-32 weeks
Overview
Cagrilintide is a long-acting synthetic analog of amylin, a pancreatic hormone co-secreted with insulin. When combined with semaglutide (as CagriSema), Phase 2 trials showed additive weight loss effects exceeding 15% over 32 weeks. Amylin analogs work through complementary pathways to GLP-1 agonists, making the combination particularly potent for metabolic research.
Key Benefits
Mechanism of Action
Cagrilintide acts on amylin receptors in the area postrema and hypothalamus to reduce food intake, slow gastric emptying, and suppress glucagon secretion. Its long half-life (approximately 7 days) allows for once-weekly dosing. The mechanism is complementary to GLP-1 agonism, targeting different neural circuits for appetite suppression.
Dosing Protocol
Typical Dose
1.2 mg once weekly
Dose Range
0.3-2.4 mg/week
Frequency
Once weekly
Route
Subcutaneous injection
Cycle Length
12-32 weeks
CLINICAL NOTES
Start at 0.3 mg weekly for 4 weeks. Titrate slowly to minimize GI side effects. Often combined with semaglutide.
Side Effects & Safety
IMPORTANT DISCLAIMER
This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.
Research References
Frequently Asked Questions
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