5-Amino-1MQ

5-Amino-1-methylquinolinium · NNMT inhibitor

NNMT inhibitor that promotes fat oxidation inside adipocytes without appetite suppression

Typical Dose

50-100 mg once daily

Route

Oral

Frequency

Once or twice daily

Cycle

8-16 weeks

Overview

5-Amino-1MQ is a small molecule that inhibits Nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue. By inhibiting NNMT, it is proposed to increase NAD+ and SAM availability in fat cells, promoting fat oxidation and reducing adipocyte size. Animal studies have shown significant reductions in fat mass without changes in food intake.

Key Benefits

Adipocyte size reduction

Fat oxidation promotion

Metabolic rate enhancement

Potential synergy with NAD+ precursors

No appetite suppression (weight loss without hunger)

Improved insulin sensitivity

Mechanism of Action

5-Amino-1MQ inhibits NNMT, reducing the consumption of SAM in adipose tissue. This increases SAM availability for methylation reactions and raises NAD+ levels in fat cells. Elevated NAD+ activates SIRT1 in adipocytes, promoting fat oxidation and reducing lipid accumulation.

Dosing Protocol

Typical Dose

50-100 mg once daily

Dose Range

50-150 mg/day

Frequency

Once or twice daily

Route

Oral capsule

Cycle Length

8-16 weeks

CLINICAL NOTES

Take with food. Effects may take 4-8 weeks to become apparent. Can be combined with NAD+ precursors for synergistic metabolic effects.

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Side Effects & Safety

Generally well tolerated in animal studies

Limited human safety data

Potential GI discomfort

Unknown long-term effects

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.