Tesofensine

NS2330 · Triple Reuptake Inhibitor

Triple monoamine reuptake inhibitor with potent appetite suppression and weight loss

Typical Dose

0.5 mg once daily

Route

Oral

Frequency

Once daily (morning)

Cycle

12-24 weeks

Overview

Tesofensine is a novel triple monoamine reuptake inhibitor that blocks the reuptake of serotonin, dopamine, and norepinephrine. Originally developed for neurological conditions, it was found to produce significant weight loss in clinical trials. Phase 2 trials for obesity showed weight reductions of 6.5-12.8% over 24 weeks.

Key Benefits

Potent appetite suppression

Increased energy expenditure

Significant body weight reduction

Reduced food cravings and reward

Potential mood enhancement

Metabolic rate increase

Mechanism of Action

Tesofensine inhibits the reuptake transporters for serotonin (SERT), dopamine (DAT), and norepinephrine (NET), increasing the synaptic availability of all three monoamines. This produces appetite suppression through serotonergic and dopaminergic pathways, increased energy expenditure through noradrenergic activation, and enhanced satiety signaling.

Dosing Protocol

Typical Dose

0.5 mg once daily

Dose Range

0.25-1 mg/day

Frequency

Once daily (morning)

Route

Oral capsule

Cycle Length

12-24 weeks

CLINICAL NOTES

Start at 0.25 mg daily. Monitor heart rate and blood pressure. Take in the morning to avoid insomnia.

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Reconstitution calculator and cycle planner pre-filled with Tesofensine defaults

Side Effects & Safety

Increased heart rate

Elevated blood pressure

Dry mouth

Insomnia

Nausea

Constipation

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.