Ipamorelin

GHRP-1 Analog · Growth Hormone Secretagogue

A selective GH secretagogue with minimal side effects

Typical Dose

200–300 mcg per dose

Route

Subcutaneous

Frequency

1–3 times daily, ideally before bed

Cycle

8–12 weeks

Overview

Ipamorelin is often called the "cleanest" growth hormone peptide available, and for good reason. It triggers a pulse of growth hormone from your pituitary gland without significantly raising cortisol (the stress hormone) or prolactin (a hormone that can cause unwanted side effects). Think of it as a precise, targeted signal that says "release growth hormone now" without accidentally triggering other hormonal responses. It is most commonly paired with CJC-1295 for a powerful but well-tolerated combination.

Key Benefits

Selective growth hormone release

Minimal impact on cortisol and prolactin

Improves body composition

Enhances recovery and sleep

Anti-aging effects

Increases bone density

Mechanism of Action

Ipamorelin mimics ghrelin — the hormone your stomach releases when you are hungry, which also signals the pituitary to release growth hormone. By binding to the ghrelin receptor in the pituitary, Ipamorelin triggers a clean GH pulse. Unlike older growth hormone peptides (like GHRP-6), it is highly selective, meaning it only activates the growth hormone pathway and leaves cortisol and prolactin largely untouched. This selectivity is what makes it so popular for long-term use.

Dosing Protocol

Typical Dose

200–300 mcg per dose

Dose Range

100–500 mcg per dose

Frequency

1–3 times daily, ideally before bed

Route

Subcutaneous injection

Cycle Length

8–12 weeks

CLINICAL NOTES

Best taken 30–60 minutes before bed to align with the natural nocturnal GH pulse. Avoid eating 2 hours before injection for best results.

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Side Effects & Safety

Mild water retention

Tingling sensation

Increased hunger

Injection site reactions

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.