🩹 Healing & RecoveryPreclinical

Wolverine Stack

BPC-157 + TB-500 · The Healing Stack

The most popular healing peptide combination — synergistic local and systemic repair

Typical Dose

1 mg once daily (Weeks 1–4)

Route

Subcutaneous

Frequency

Once daily; every other day for maintenance

Cycle

8+ weeks with maintenance phase

Overview

The Wolverine Stack combines BPC-157 and TB-500 into a single protocol that addresses both localized and systemic healing simultaneously. Named after the Marvel character known for rapid regeneration, this combination is considered the gold standard healing protocol in the peptide community. BPC-157 handles targeted, localized repair while TB-500 provides systemic anti-inflammatory and healing support throughout the body.

Key Benefits

Combines localized healing (BPC-157) with systemic recovery (TB-500)
Accelerates healing of acute injuries significantly faster than either alone
Reduces systemic inflammation while repairing specific tissue damage
Supports gut health alongside musculoskeletal recovery
Promotes angiogenesis and new tissue formation
Considered the most comprehensive healing protocol available

Mechanism of Action

BPC-157 upregulates growth hormone receptors in tendon fibroblasts and promotes angiogenesis through VEGF, providing targeted healing at the injury site. TB-500 upregulates actin expression throughout the body, promoting cell migration and systemic tissue repair while reducing inflammation via cytokine modulation. Together, they address healing from both a local and systemic perspective simultaneously.

Dosing Protocol

Typical Dose

1 mg once daily (Weeks 1–4)

Dose Range

1–2 mg/day

Frequency

Once daily; every other day for maintenance

Route

Subcutaneous injection (abdomen or near injury site)

Cycle Length

8+ weeks with maintenance phase

CLINICAL NOTES

Titration schedule: Weeks 1–4: inject 1 mg (1,000 mcg) once daily. Weeks 5–8: increase to 2 mg (2,000 mcg) daily if additional benefit is needed. Maintenance (beyond Week 8): inject 1–2 mg every other day as needed for continued healing support. Inject near the injury site for best localized effect.

Reconstitution calculator and cycle planner pre-filled with Wolverine Stack defaults

Reconstitution Guide

Vial Size

40 mg (BPC-157 20mg + TB-500 20mg)

BAC Water

4 mL (400 units)

Concentration

5 mg/mL of each compound

STEP-BY-STEP INSTRUCTIONS

Pop off the caps on the bacteriostatic water and the peptide vial, then wipe with alcohol prep pads. Draw 4 mL (400 units) of bacteriostatic water and inject it into the vial containing the combined 20 mg BPC-157 + 20 mg TB-500 powder. The solution is now 5 mg/mL of each compound.

DRAW VOLUME REFERENCE

DoseUnits (U-100)Volume (mL)
500 mcg10 units0.10 mL
1 mg20 units0.20 mL
2 mg40 units0.40 mL

STORAGE

Once reconstituted: store vial in the refrigerator (36–46°F / 2–8°C) and use within 30–60 days for best potency.

Side Effects & Safety

Combined side effects of both peptides (generally mild)
Injection site reactions
Temporary fatigue (TB-500)
Nausea (rare, BPC-157)

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.

Research References

Frequently Asked Questions

Quick Reference

CategoryHealing & Recovery
Research StatusPreclinical
Typical Dose1 mg once daily (Weeks 1–4)
RouteSubcutaneous
Cycle8+ weeks with maintenance phase

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