Glutathione
GSH · L-Glutathione · Master Antioxidant
The body's master antioxidant for detoxification, immune support, and anti-aging
Typical Dose
600 mg 2-3x weekly
Route
Subcutaneous
Frequency
2-3x weekly or daily
Cycle
Ongoing
Overview
Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. It is the most abundant intracellular antioxidant in the human body and plays a central role in protecting cells from oxidative damage, supporting immune function, and facilitating detoxification. Glutathione levels decline with age, chronic illness, and environmental toxin exposure.
Key Benefits
Mechanism of Action
Glutathione acts as a direct antioxidant by donating electrons to neutralize reactive oxygen species (ROS). It is a cofactor for glutathione peroxidase enzymes that detoxify hydrogen peroxide and lipid peroxides. GSH also conjugates with toxins and heavy metals via glutathione S-transferases to facilitate their excretion, and regenerates vitamins C and E.
Dosing Protocol
Typical Dose
600 mg 2-3x weekly
Dose Range
200-1200 mg per session
Frequency
2-3x weekly or daily
Route
Subcutaneous injection or IV infusion
Cycle Length
Ongoing
CLINICAL NOTES
IV administration provides highest bioavailability. Can be combined with Vitamin C for enhanced antioxidant effect. Administer slowly.
Side Effects & Safety
IMPORTANT DISCLAIMER
This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.
Research References
Common Stacks
Glutathione is a master antioxidant that supports any protocol by reducing oxidative stress.
NAD+ + Glutathione is a powerful antioxidant and cellular energy stack.
GHK-Cu's anti-inflammatory effects are amplified by Glutathione's antioxidant protection.
Methylene blue's pro-oxidant/antioxidant cycling works synergistically with Glutathione.
Frequently Asked Questions
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Related Peptides
Compounds often researched alongside Glutathione
NAD+
The master coenzyme for cellular energy, DNA repair, and sirtuin-driven longevity
MOTS-c
A mitochondria-derived peptide for metabolic health and longevity
Thymosin Alpha-1
A thymus-derived peptide for immune modulation and antiviral defense
GHK-Cu
A natural copper-binding peptide for skin health and wound healing