Melanotan II

MT-2 · Melanotan 2

A melanocortin peptide that promotes tanning, libido, and sexual function

Typical Dose

0.5–1 mg per dose

Route

Subcutaneous

Frequency

Daily during loading phase, then as needed

Cycle

2–4 weeks loading, then maintenance as needed

Overview

Melanotan II started as a sunless tanning project and ended up being one of the most talked-about peptides in the biohacking world. It is a synthetic version of a hormone your body naturally produces to control skin pigmentation. Researchers discovered it had powerful effects on sexual arousal and libido as a side effect — which ended up being more interesting to many users than the tanning. It also suppresses appetite. It is one of the more potent peptides on this site and comes with a meaningful side effect profile, so it requires careful consideration.

Key Benefits

Promotes skin tanning without UV exposure

Significantly enhances libido and sexual arousal in both sexes

Improves erectile function in men

May reduce appetite and support fat loss

Increases spontaneous erections

Potential protective effects against UV-induced skin damage

Mechanism of Action

Melanotan II activates a family of receptors called melanocortin receptors, which are found throughout your body. Different receptors do different things. The ones in your skin cells (MC1R) respond by producing more melanin — the pigment that makes skin darker. The ones in your brain (MC3R and MC4R) control sexual arousal and appetite. By activating all of these at once, Melanotan II produces tanning, increased libido, and appetite suppression simultaneously. This broad activation is also why the side effect profile is more significant than more targeted peptides.

Dosing Protocol

Typical Dose

0.5–1 mg per dose

Dose Range

0.25–2 mg per dose

Frequency

Daily during loading phase, then as needed

Route

Subcutaneous injection

Cycle Length

2–4 weeks loading, then maintenance as needed

CLINICAL NOTES

Start with a very low dose (0.25 mg) to assess tolerance due to nausea. Administer in the evening to minimize side effects. Tanning effects require some UV exposure to activate. Not recommended for individuals with a history of melanoma.

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Side Effects & Safety

Nausea (very common, especially at higher doses)

Facial flushing

Spontaneous erections (in men)

Darkening of existing moles

Fatigue and yawning

Increased blood pressure

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.