Kisspeptin-10

KP-10 · Metastin 45-54

A hypothalamic peptide that regulates reproductive hormones and sexual motivation

Typical Dose

1–3 mcg/kg body weight per dose

Route

Subcutaneous

Frequency

Pulsatile dosing — every 90 minutes (mimics natural rhythm) or 1–2 times daily

Cycle

Varies by indication — typically 4–8 weeks

Overview

Kisspeptin-10 is the shortest active fragment of kisspeptin, a neuropeptide encoded by the KISS1 gene. It plays a critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis, which controls the production of LH, FSH, testosterone, and estrogen. It is being studied for fertility treatment, hypogonadism, and sexual function.

Key Benefits

Stimulates LH and FSH release, boosting testosterone and estrogen

Improves sexual motivation and arousal

Potential treatment for hypogonadotropic hypogonadism

May improve fertility in both men and women

Regulates puberty and reproductive function

Being studied as an alternative to TRT for maintaining natural testosterone production

Mechanism of Action

Kisspeptin-10 binds to the KISS1R receptor (GPR54) on GnRH neurons in the hypothalamus, triggering a pulsatile release of GnRH. This stimulates the pituitary to release LH and FSH, which in turn stimulate the gonads to produce testosterone (in men) and estrogen/progesterone (in women). This makes it a master regulator of the entire reproductive hormone cascade.

Dosing Protocol

Typical Dose

1–3 mcg/kg body weight per dose

Dose Range

0.5–10 mcg/kg per dose

Frequency

Pulsatile dosing — every 90 minutes (mimics natural rhythm) or 1–2 times daily

Route

Subcutaneous injection or intravenous (clinical)

Cycle Length

Varies by indication — typically 4–8 weeks

CLINICAL NOTES

Pulsatile administration is critical — continuous infusion leads to receptor desensitization and paradoxical suppression of LH. For most users, 1–2 daily injections are practical. Research protocols often use 1 mcg/kg doses.

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Side Effects & Safety

Mild flushing

Nausea (rare)

Receptor desensitization with continuous use

Generally well tolerated in clinical studies

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.