🛡️ Immune SupportPreclinical

VIP

Vasoactive Intestinal Peptide · VIP 28 · VIP neuropeptide

Potent anti-inflammatory neuropeptide studied for POTS, MCAS, and immune modulation

Typical Dose

100 mcg once daily

Route

Subcutaneous

Frequency

Once or twice daily

Cycle

4-12 weeks

Overview

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide found throughout the nervous system, GI tract, and immune system. Research has explored VIP for its potent anti-inflammatory and immunomodulatory properties, its role in circadian rhythm regulation, neuroprotection, and its potential in treating conditions such as POTS, MCAS, and chronic inflammatory conditions.

Key Benefits

Potent anti-inflammatory effects

Vasodilation and improved blood flow

Immune modulation (Treg promotion)

Neuroprotection

Circadian rhythm regulation

Potential benefit in POTS and dysautonomia

GI motility regulation

Mechanism of Action

VIP binds to VPAC1 and VPAC2 receptors, increasing intracellular cAMP. This leads to smooth muscle relaxation (vasodilation), inhibition of pro-inflammatory cytokines (TNF-alpha, IL-6, IL-12), promotion of anti-inflammatory cytokines (IL-10), and modulation of T-cell and dendritic cell function.

Dosing Protocol

Typical Dose

100 mcg once daily

Dose Range

50-200 mcg/day

Frequency

Once or twice daily

Route

Subcutaneous injection or intranasal

Cycle Length

4-12 weeks

CLINICAL NOTES

Intranasal delivery is preferred for CNS applications. Monitor blood pressure due to vasodilatory effects.

Save to Library

Reconstitution calculator and cycle planner pre-filled with VIP defaults

Side Effects & Safety

Flushing

Hypotension (dose-dependent)

Nausea

Headache

Facial flushing

IMPORTANT DISCLAIMER

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol. Individual responses vary and medical supervision is recommended.